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NOD mice and autoimmunity.

Autoimmunity reviews - 1 Jul 2005

Aoki Christopher A, Borchers Andrea T, Ridgway William M, Keen Carl L, Ansari Aftab A, Gershwin M Eric

Abstract excerpt

The NOD mouse has been an important model of type 1 diabetes and autoimmune diseases for over 20 years. Experimental and genetic manipulations of the NOD mouse have demonstrated a broad susceptibility to multiple autoimmune syndromes. This predisposition to autoimmunity is due to defects in both central and peripheral tolerance. The defect of central tolerance is likely secondary to improper negative selection...

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PMID: 16081028
DOI: 10.1016/j.autrev.2005.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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