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Article

Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004

Koarada Syuichi, Wu Yuehong, Fertig Noreen, Sass David A, Nalesnik Michael, Todd John A, Lyons Paul A, Fenyk-Melody Judith, Rainbow Daniel B, Wicker Linda S, Peterson Laurence B, Ridgway William M

Abstract excerpt

At least 20 insulin-dependent diabetes (Idd) loci modify the progression of autoimmune diabetes in the NOD mouse, an animal model of human type 1 diabetes. The NOD.c3c4 congenic mouse, which has multiple B6- and B10-derived Idd-resistant alleles on chromosomes 3 and 4, respectively, is completely protected from autoimmune diabetes. We demonstrate in this study, however, that NOD.c3c4 mice develop a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15294944
DOI: 10.4049/jimmunol.173.4.2315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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