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Article

Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2006

Silveira Pablo A, Chapman Harold D, Stolp Jessica, Johnson Ellis, Cox S Lewis, Hunter Kara, Wicker Linda S, Serreze David V

Abstract excerpt

Autoreactive T cells clearly mediate the pancreatic beta cell destruction causing type 1 diabetes (T1D). However, studies in NOD mice indicate that B cells also contribute to pathogenesis because their ablation by introduction of an Igmunull mutation elicits T1D resistance. T1D susceptibility is restored in NOD.Igmunull mice that are irradiated and reconstituted with syngeneic bone marrow plus NOD B cells, but...

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Source

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Identifiers

PMID: 17082619
DOI: 10.4049/jimmunol.177.10.7033
PMCID: PMC2886968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.PMID 17082619Read ↗

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