Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2008

Sgouroudis Evridiki, Albanese Alexandre, Piccirillo Ciriaco A

Abstract excerpt

Type I diabetes (T1D) susceptibility is inherited through multiple insulin-dependent diabetes (Idd) genes. NOD.B6 Idd3 congenic mice, introgressed with an Idd3 allele from T1D-resistant C57BL/6 mice (Idd3(B6)), show a marked resistance to T1D compared with control NOD mice. The protective function of the Idd3 locus is confined to the Il2 gene, whose expression is critical for naturally occurring CD4(+)Foxp3(+)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Forkhead Transcription Factors
Share to Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Cellular

Share to Interleukin-2

Share to Mice, Congenic

Share to Mice, Inbred NOD

Share to Pancreas

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 18941219
DOI: 10.4049/jimmunol.181.9.6283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.PMID 18941219Read ↗

IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice.Semantic proximity Read ↗

Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.Semantic proximity Read ↗

The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes.Semantic proximity Read ↗

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Semantic proximity Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.Semantic proximity Read ↗

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.Semantic proximity Read ↗

A 20-Mb region of chromosome 4 controls TNF-alpha-mediated CD8+ T cell aggression toward beta cells in type 1 diabetes.Semantic proximity Read ↗

Gata3 is detrimental to regulatory T cell function in autoimmune diabetesSemantic proximity Read ↗

Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.Semantic proximity Read ↗

Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.Semantic proximity Read ↗

Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.