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Article

THE NOD MOUSE: A Model of Immune Dysregulation

29 Nov 2004

Abstract excerpt

Autoimmunity is a complex process that likely results from the summation of multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of autoimmune disease and an important tool for dissecting tolerance mechanisms. The strength of this mouse strain is that it develops spontaneous autoimmune diabetes, which shares many similarities to autoimmune or type 1a diabetes (T1D) in human...

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Identifiers

PMID: 15771578
DOI: 10.1146/annurev.immunol.23.021704.115643

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