Article
Immunosuppressant FK506 induces sustained activation of MAP kinase and promotes neurite outgrowth in PC12 mutant cells incapable of differentiating.
Cell structure and function - 1 Oct 2002
Kano Yoshio, Hiragami Fukumi, Kawamura Kenji, Kimata Yuko, Nakagiri Sachiko, Poffenberger Chikako K, Akiyama Junichi, Okishima Kyota, Koike Yoshihisa, Gomita Yutaka
Abstract excerpt
During the continuous culturing of neural PC12 cells, a drug hypersensitive PC12 mutant cell line (PC12m3) was obtained, which demonstrated high neurite outgrowth when stimulated by various drugs. When the immunosuppressant drug FK506 and nerve growth factor (NGF) were introduced to the PC12m3 cells, the frequency of neurite outgrowth increased approximately 40-fold for NGF alone. However, the effect of FK506 on...
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