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Article

Borna Disease Virus Persistent Infection Activates Mitogen-activated Protein Kinase and Blocks Neuronal Differentiation of PC12 Cells

1 Mar 2001

Abstract excerpt

Persistence of Borna disease virus (BDV) in the central nervous system causes damage to specific neuronal populations. BDV is noncytopathic, and the mechanisms underlying neuronal pathology are not well understood. One hypothesis is that infection affects the response of neurons to factors that are crucial for their proliferation, differentiation, or survival. To test this hypothesis, we analyzed the response of...

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PMID: 11073944
DOI: 10.1074/jbc.m005107200

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Source receipt: pubmed, retrieved 7 Sept 2026.

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