Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Jun promotes neurite outgrowth and survival in PC12 cells.

Brain research. Molecular brain research - 10 Nov 2000

Dragunow M, Xu R, Walton M, Woodgate A, Lawlor P, MacGibbon G A, Young D, Gibbons H, Lipski J, Muravlev A, Pearson A, During M

Abstract excerpt

We investigated the function of c-Jun in PC12 cells by transfecting them with a plasmid containing a c-Jun cDNA transcription cassette. Transfected cells expressed high levels of c-Jun mRNA and protein and demonstrated an increase in both AP-1 DNA binding and gene activation. The c-Jun over-expressing cells showed marked neurite outgrowth but no evidence of spontaneous cell death. In fact, c-Jun over-expressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Nerve Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neurites

Share to Okadaic Acid

Share to PC12 Cells

Share to Proto-Oncogene Proteins c-jun

Share to Sodium Channels

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 11072092
DOI: 10.1016/s0169-328x(00)00191-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Jun promotes neurite outgrowth and survival in PC12 cells.PMID 11072092Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

The signal transduction pathway underlying ion channel gene regulation by SP1-C-Jun interactions.Semantic proximity Read ↗

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.Semantic proximity Read ↗

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway.Semantic proximity Read ↗

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.Semantic proximity Read ↗

c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells.Semantic proximity Read ↗

Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells.Semantic proximity Read ↗

c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.Semantic proximity Read ↗

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.Semantic proximity Read ↗

Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2.Semantic proximity Read ↗

CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity.Semantic proximity Read ↗

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.