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Article

Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.

Molecular and cellular biology - 1 Dec 2004

Silverman Eran, Frödin Morten, Gammeltoft Steen, Maller James L

Abstract excerpt

We investigated the role of Rsk proteins in the nerve growth factor (NGF) signaling pathway in PC12 cells. When rat Rsk1 or murine Rsk2 proteins were transiently expressed, NGF treatment (100 ng/ml for 3 days) caused three- and fivefold increases in Rsk1 and Rsk2 activities, respectively. Increased activation of both wild-type Rsk proteins could be achieved by coexpression of a constitutively active (CA)...

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Source

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Identifiers

PMID: 15572664
DOI: 10.1128/MCB.24.24.10573-10583.2004
PMCID: PMC533971

Genes

NGF
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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