Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.

Journal of cell science - 1 Feb 1996

Jackson T R, Blader I J, Hammonds-Odie L P, Burga C R, Cooke F, Hawkins P T, Wolf A G, Heldman K A, Theibert A B

Abstract excerpt

Application of nerve growth factor (NGF) to PC12 cells stimulates a programme of physiological changes leading to the development of a sympathetic neuron like phenotype, one aspect of which is the development of a neuronal morphology characterised by the outgrowth of neuritic processes. We have investigated the role of phosphoinositide 3-kinase in NGF-stimulated morphological differentiation through two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Mutation

Share to Nerve Growth Factors

Share to Phosphatidylinositol 3-Kinases

Share to Phosphotransferases (Alcohol Group Acceptor)

Source

Open in PubMed Open full text

Identifiers

PMID: 8838652
DOI: 10.1242/jcs.109.2.289
PMCID: PMC4303253

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.PMID 8838652Read ↗

IP3 3-kinase opposes NGF driven neurite outgrowth.Semantic proximity Read ↗

NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth.Semantic proximity Read ↗

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Semantic proximity Read ↗

Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

c-Jun promotes neurite outgrowth and survival in PC12 cells.Semantic proximity Read ↗

Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells.Semantic proximity Read ↗

Nerve growth factor stimulates diacylglycerol de novo synthesis and phosphatidylinositol hydrolysis in pheochromocytoma cells.Semantic proximity Read ↗

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNSSemantic proximity Read ↗

Differences in early and late responses between neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y neuroblastoma cells.Semantic proximity Read ↗

NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating.Semantic proximity Read ↗

Borna Disease Virus Persistent Infection Activates Mitogen-activated Protein Kinase and Blocks Neuronal Differentiation of PC12 CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.