Article
Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.
Journal of cell science - 1 Feb 1996
Jackson T R, Blader I J, Hammonds-Odie L P, Burga C R, Cooke F, Hawkins P T, Wolf A G, Heldman K A, Theibert A B
Abstract excerpt
Application of nerve growth factor (NGF) to PC12 cells stimulates a programme of physiological changes leading to the development of a sympathetic neuron like phenotype, one aspect of which is the development of a neuronal morphology characterised by the outgrowth of neuritic processes. We have i...
Topics
- Androstadienes
- Animals
- Calcium
- Enzyme Activation
- Enzyme Inhibitors
- Mutation
- Nerve Growth Factors
- Neurites
- PC12 Cells
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Rats
- Wortmannin