Article
Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor.
Journal of neuroscience research - 1 Jan 2001
Hughes A L, Messineo-Jones D, Lad S P, Neet K E
Abstract excerpt
The common neurotrophin receptor p75(NTR) (low affinity nerve growth factor receptor) participates in the high-affinity binding with the TrkA nerve growth factor (NGF) receptor, may mediate apoptosis, and may signal independently in a cell-specific manner. The potential of p75(NTR) to signal independently of TrkA was investigated with an NGF mutant protein (NGFdelta9/13) that binds poorly to TrkA (Woo et al....
Topics
- Animals
- Apoptosis
- Caspase 3
- Caspases
- Cell Cycle
- Cell Differentiation
- Cell Survival
- Culture Media, Serum-Free
- Mutation
- NF-kappa B
- Nerve Growth Factor
- Neurites
- PC12 Cells
- Rats
- Receptor, Nerve Growth Factor