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Article

Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells.

Journal of neurochemistry - 1 Jun 2005

Azoitei Ninel, Wirth Thomas, Baumann Bernd

Abstract excerpt

We examined the role of the IkappaB kinase complex in nerve growth factor (NGF)-induced neuronal differentiation of PC12 cells. We showed that neurite outgrowth is accompanied by an activation of the IKK complex and a delayed elevation of NF-kappaB-dependent transcription. Ectopic expression of a constitutively active form of IKK2 but not of IKK1 promoted neurite outgrowth in the absence of NGF. In addition,...

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Identifiers

PMID: 15935065
DOI: 10.1111/j.1471-4159.2005.03148.x

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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