Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells.

Journal of neuroscience research - 1 Sept 2002

Ito Hisanori, Nomoto Hiroshi, Furukawa Shoei

Abstract excerpt

Mutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease proliferation and extend long processes when transfected with NGF cDNA. PC84 cells expressed a high level of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase
Share to Dose-Response Relationship, Drug
Share to Nerve Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to PC12 Cells

Share to Receptor, Nerve Growth Factor

Share to Receptor, trkA

Share to Receptors, Nerve Growth Factor

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12210831
DOI: 10.1002/jnr.10359

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells.PMID 12210831Read ↗

NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

Inhibition of neuronal phenotype by PTEN in PC12 cells.Semantic proximity Read ↗

Immunosuppressant FK506 induces neurite outgrowth in PC12 mutant cells with impaired NGF-promoted neuritogenesis via a novel MAP kinase signaling pathway.Semantic proximity Read ↗

Immunosuppressant FK506 induces sustained activation of MAP kinase and promotes neurite outgrowth in PC12 mutant cells incapable of differentiating.Semantic proximity Read ↗

Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.Semantic proximity Read ↗

Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor.Semantic proximity Read ↗

Borna Disease Virus Persistent Infection Activates Mitogen-activated Protein Kinase and Blocks Neuronal Differentiation of PC12 CellsSemantic proximity Read ↗

A comparison of nerve growth factor binding protocols with native and mutant PC12 cells.Semantic proximity Read ↗

Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.Semantic proximity Read ↗

c-Jun promotes neurite outgrowth and survival in PC12 cells.Semantic proximity Read ↗

NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.