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Article

Immunosuppressant FK506 induces neurite outgrowth in PC12 mutant cells with impaired NGF-promoted neuritogenesis via a novel MAP kinase signaling pathway.

Neurochemical research - 1 Dec 2002

Kano Yoshio, Nohno Tsutomu, Hasegawa Toru, Takahashi Rei, Hiragami Fukumi, Kawamura Kenji, Iwama Michael K, Motoda Hirotoshi, Miyamoto Kanji

Abstract excerpt

We obtained a drug-hypersensitive PC12 mutant cell (PC12m3), in which neurite outgrowth was strongly stimulated by various drugs such as FK506, calcimycin and cAMP, under the condition of NGF treatment. The frequency of neurite outgrowth stimulated by FK506 was approximately 40 times greater than by NGF alone. The effects of FK506 on neurite outgrowth in PC12m3 cells were inhibited by rapamycin, an FK506...

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Source

Identifiers

PMID: 12515319
DOI: 10.1023/a:1021639128120

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Immunosuppressant FK506 induces neurite outgrowth in PC12 mutant cells with impaired NGF-promoted neuritogenesis via a novel MAP kinase signaling pathway.PMID 12515319Read ↗

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