Article
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.
Cell - 17 Jun 1994
Cowley S, Paterson H, Kemp P, Marshall C J
Abstract excerpt
The MAP kinase pathway is activated by a wide variety of external signals leading to cell proliferation or differentiation. However, it is not clear whether activation of this pathway is required for cellular responses or whether it is only one branch point in signal transduction. To investigate...
Topics
- 3T3 Cells
- Alanine
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Culture Media, Serum-Free
- DNA
- Enzyme Activation
- Glutamates
- Glutamic Acid
- Mice
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Neurites
- Neurons
- PC12 Cells