Article
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.
Cell - 17 Jun 1994
Cowley S, Paterson H, Kemp P, Marshall C J
Abstract excerpt
The MAP kinase pathway is activated by a wide variety of external signals leading to cell proliferation or differentiation. However, it is not clear whether activation of this pathway is required for cellular responses or whether it is only one branch point in signal transduction. To investigate these questions, we generated constitutively activated and interfering mutants of MAP kinase kinase 1. The activated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.