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Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells.

Current biology : CB - 1 Feb 1995

Vetter M L, Bishop J M

Abstract excerpt

BACKGROUND: Platelet-derived growth factor (PDGF) promotes mitogenesis in fibroblast cell lines but stimulates neurite outgrowth in PC12 cells that ectopically express the beta PDGF receptor. To determine which substrates must associate with this receptor protein-tyrosine kinase in order to promote neurite outgrowth, we introduced into PC12 pheochromocytoma cells three mutant forms of the beta PDGF receptor that...

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Identifiers

PMID: 7743180
DOI: 10.1016/s0960-9822(95)00038-8

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