Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells.

doi:10.1016/s0960-9822(95)00038-8

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Article

Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells.

Current biology : CB - 1 Feb 1995

Vetter M L, Bishop J M

Abstract excerpt

BACKGROUND: Platelet-derived growth factor (PDGF) promotes mitogenesis in fibroblast cell lines but stimulates neurite outgrowth in PC12 cells that ectopically express the beta PDGF receptor. To determine which substrates must associate with this receptor protein-tyrosine kinase in order to promo...

Topics

Animals
Cell Division
Enzyme Activation
GTPase-Activating Proteins
Intracellular Signaling Peptides and Proteins
Isoenzymes
Mutation
Neurites
PC12 Cells
Phosphatidylinositol 3-Kinases
Phospholipase C gamma
Phosphotransferases (Alcohol Group Acceptor)
Platelet-Derived Growth Factor
Protein Kinases
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases
Proteins

Source

Open in PubMed

Identifiers

PMID: 7743180
DOI: 10.1016/s0960-9822(95)00038-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7743180-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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