Article
NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating.
Journal of cellular biochemistry - 1 Sept 1998
Yaka R, Gamliel A, Gurwitz D, Stein R
Abstract excerpt
Activation of receptor tyrosine kinases stimulates a diverse array of cellular responses such as proliferation and differentiation. The first events in the signal transduction pathways mediated by different receptor tyrosine kinases are similar and include activation of the mitogen-activated protein kinase (MAPK) pathway and the induction of immediate early genes. The precise signaling pathways leading to each of...
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