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Article

Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.

Oncogene - 13 Apr 2000

Eggert A, Ikegaki N, Liu X, Chou T T, Lee V M, Trojanowski J Q, Brodeur G M

Abstract excerpt

Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates a cascade of signaling events leading to neuronal differentiation in vitro and might play an important role in the differentiation of favorable neuroblastomas (NB) in vivo. To study TrkA signal transduction pathways and their effects on differentiation in NB, we stably expressed wild-type TrkA and five different TrkA...

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Source

Identifiers

PMID: 10803465
DOI: 10.1038/sj.onc.1203518

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.PMID 10803465Read ↗

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