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Article

Inhibition of neuronal phenotype by PTEN in PC12 cells.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004

Musatov Sergei, Roberts Jill, Brooks Andrew I, Pena John, Betchen Simone, Pfaff Donald W, Kaplitt Michael G

Abstract excerpt

The mechanisms of neuronal differentiation in PC12 cells are still not completely understood. Here, we report that the tumor suppressor PTEN has a profound effect on differentiation by affecting several pathways involved in nerve growth factor (NGF) signaling. When overexpressed in PC12 cells, PTEN (phosphatase and tensin homologue deleted on chromosome ten) blocked neurite outgrowth induced by NGF. In addition,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 14990793
DOI: 10.1073/pnas.0308289101
PMCID: PMC373513

Genes

PTEN
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of neuronal phenotype by PTEN in PC12 cells.PMID 14990793Read ↗

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