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Article

NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth.

Neurochemistry international - 1 Jan 2000

Jin Erika, Nosaka Kazuto, Sano Mamoru

Abstract excerpt

Two signaling pathways, phosphoinositide 3-kinase (PI-3k)/Akt and Ras/MAPK, are major effectors triggered by nerve growth factor (NGF). Rac1, Cdc42 and GSK-3beta are reported to be targets of PI-3k in the signal transduction for neurite outgrowth. Immediately after NGF was added, broad ruffles were observed temporarily around the periphery of PC12 cells prior to neurite growth. As PC12D cells are characterized by...

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Identifiers

PMID: 17561310
DOI: 10.1016/j.neuint.2007.04.032

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth.PMID 17561310Read ↗

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