Article
Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia. Evidence for a founder effect.
Cancer - 15 May 2002
Rozen Paul, Naiman Tova, Strul Hana, Taussky Philipp, Karminsky Nataly, Shomrat Ruth, Samuel Ziona, Yaron Yuval, Orr-Urtreger Avi
Abstract excerpt
BACKGROUND: The authors previously found the I1307K adenomatous polyposis coli (APC) gene variant in 5% of Ashkenazi control participants, in 15.4% of those who had familial colorectal neoplasia, but also in 1.6% of non-Ashkenazi control participants. In this study, they evaluated its use in a screening program for familial colorectal neoplasia and examined for a founder effect. METHODS: Consecutive Ashkenazim...
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