Article
The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews.
Nature genetics - 1 Sept 1998
Woodage T, King S M, Wacholder S, Hartge P, Struewing J P, McAdams M, Laken S J, Tucker M A, Brody L C
Abstract excerpt
Mutations in APC are classically associated with familial adenomatous polyposis (FAP), a highly penetrant autosomal dominant disorder characterized by multiple intestinal polyps and, without surgical intervention, the development of colorectal cancer (CRC). APC is a tumour-suppressor gene, and somatic loss occurs in tumours. The germline T-to-A transversion responsible for the APC I1307K allele converts the...
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