The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews.

doi:10.1038/1722

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Article

The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews.

Nature genetics - 1 Sept 1998

Woodage T, King S M, Wacholder S, Hartge P, Struewing J P, McAdams M, Laken S J, Tucker M A, Brody L C

Abstract excerpt

Mutations in APC are classically associated with familial adenomatous polyposis (FAP), a highly penetrant autosomal dominant disorder characterized by multiple intestinal polyps and, without surgical intervention, the development of colorectal cancer (CRC). APC is a tumour-suppressor gene, and so...

Topics

Adenomatous Polyposis Coli Protein
Adult
Aged
Aged, 80 and over
Alleles
BRCA1 Protein
Breast Neoplasms
Colorectal Neoplasms
Cytoskeletal Proteins
Europe
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Jews
Male
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 9731533
DOI: 10.1038/1722

Genes

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9731533-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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