Article
APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews.
Gastroenterology - 1 Feb 2001
Stern H S, Viertelhausen S, Hunter A G, O'Rourke K, Cappelli M, Perras H, Serfas K, Blumenthall A, Dewar D, Baumann E, Lagarde A E
Abstract excerpt
BACKGROUND & AIMS: The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practice. To further address the pathogenic significance of I1307K, we offered both a genetic test...
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