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The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features.

Cancer genetics and cytogenetics - 1 Aug 2006

Locker Gershon Y, Kaul Karen, Weinberg David S, Gatalica Zoran, Gong Gordon, Peterman Amy, Lynch Jane, Klatzco Lucy, Olopade Olufunmilayo I, Bomzer Charles A, Newlin Anna, Keenan Eileen, Tajuddin Mohammed, Knezetic Joseph, Coronel Stephanie, Lynch Henry T

Abstract excerpt

Colorectal cancer is common in Ashkenazi Jews. The I1307K APC mutation occurs in 6-7% of Ashkenazi Jews and increases the risk of colorectal cancer. This study aimed to describe the clinical, pathologic and epidemiologic features of colorectal cancer in I1307K carriers to determine whether there were any features which might warrant individual screening for the mutation. In all, 215 Ashkenazi Jews with a personal...

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PMID: 16875934
DOI: 10.1016/j.cancergencyto.2006.03.007

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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