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Article

Position statement of the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) on APC I1307K and cancer risk.

Journal of medical genetics - 1 Nov 2023

Valle Laura, Katz Lior H, Latchford Andrew, Mur Pilar, Moreno Victor, Frayling Ian M, Heald Brandie, Capellá Gabriel

Abstract excerpt

While constitutional pathogenic variants in the APC gene cause familial adenomatous polyposis, APC c.3920T>A; p.Ile1307Lys (I1307K) has been associated with a moderate increased risk of colorectal cancer (CRC), particularly in individuals of Ashkenazi Jewish descent. However, published data include relatively small sample sizes, generating inconclusive results regarding cancer risk, particularly in non-Ashkenazi...

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Share to Adenomatous Polyposis Coli
Share to Colorectal Cancer Screening and Detection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, APC

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Identifiers

PMID: 37076288
DOI: 10.1136/jmg-2022-108984
PMCID: PMC10646901

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Position statement of the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) on APC I1307K and cancer risk.PMID 37076288Read ↗

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