Article
The I1307K polymorphism of the APC gene in colorectal cancer.
Gastroenterology - 1 Jan 1999
Prior T W, Chadwick R B, Papp A C, Arcot A N, Isa A M, Pearl D K, Stemmermann G, Percesepe A, Loukola A, Aaltonen L A, De La Chapelle A
Abstract excerpt
BACKGROUND & AIMS: Colorectal cancer is one of the most frequent cancers in humans. Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews. However, a second study indicated...
Topics
- Adenomatous Polyposis Coli Protein
- Amino Acid Sequence
- Base Sequence
- Codon
- Colorectal Neoplasms
- Cytoskeletal Proteins
- DNA
- DNA Repair
- Genes, APC
- Genetic Testing
- Humans
- Jews
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic