Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.

doi:10.1016/s0016-5085(99)70228-3

Back to search

Article

Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.

Gastroenterology - 1 Jan 1999

Rozen P, Shomrat R, Strul H, Naiman T, Karminsky N, Legum C, Orr-Urtreger A

Abstract excerpt

BACKGROUND & AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K...

Topics

Adenomatous Polyposis Coli Protein
Colorectal Neoplasms
Cytoskeletal Proteins
DNA
Female
Gene Frequency
Genes, APC
Humans
Israel
Jews
Male
Mutation
Risk Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.