Article
Phenotypic characteristics associated with the APC gene I1307K mutation in Ashkenazi Jewish patients with colorectal polyps.
JAMA - 16 Aug 2000
Syngal S, Schrag D, Falchuk M, Tung N, Farraye F A, Chung D, Wright M, Whetsell A, Miller G, Garber J E
Abstract excerpt
CONTEXT: The I1307K mutation of the APC gene is found in approximately 6% of the Ashkenazi Jewish population and is associated with elevated risk of colorectal cancer. The incidence of the mutation in patients with colorectal adenomas is unknown. OBJECTIVES: To determine the carrier rate of the I1307K mutation in Ashkenazi Jewish patients with a history of colorectal polyps but without colorectal cancer and to...
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