Article

<i>APC</i>I1307K and clinical management: insights from UK Biobank association analysis of colorectal and other cancer risks in Ashkenazi and non-Ashkenazi whites

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> APC c.3920T>A; p.Ile1307Lys (I1307K), prevalent in individuals of Ashkenazi Jewish (AJ) origin, has been associated with a modestly increased colorectal cancer (CRC) risk. Clinical recommendations for I1307K heterozygotes vary across countries and expert groups, reflecting differences in population frequencies, modest risk estimates, and limited data in non-AJ individuals. We analyzed UK Biobank...

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Literature Corpus work: 76e511b9-2a6b-57b2-b7e4-25cf0c3629cc
DOI: 10.1101/2025.04.03.25325166

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