Article
The I1307K APC polymorphism: prevalence in non-Ashkenazi Jews and evidence for a founder effect.
Genetic testing - 1 Jan 2001
Shtoyerman-Chen R, Friedman E, Figer A, Carmel M, Patael Y, Rath P, Fidder H H, Bar-Meir S, Theodor L
Abstract excerpt
A missense mutation within the APC gene, I1307K, was described in Ashkenazi individuals at risk for colorectal cancer (CRC) and in the general population. The anecdotal reporting of the occurrence of this mutation in some non-Ashkenazi individuals led us to hypothesize that within the Jewish people, the I1307K polymorphism may reflect a founder mutation, and that the mutation is not restricted to ethnic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.