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Article

Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.

Biochemical and biophysical research communications - 7 Jun 2002

Bourdi Mohammed, Reilly Timothy P, Elkahloun Abdel G, George John W, Pohl Lance R

Abstract excerpt

Idiosyncratic drug-induced hepatitis may depend upon many factors including a balance between pro- and anti-inflammatory mediator production levels. Using a guinea pig model of liver injury induced by bioactivation of the anesthetic drug, halothane, we found that toxicity was commensurate with an increase in serum macrophage migration inhibitory factor (MIF), a pro-inflammatory signal and counter-regulator of...

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Source

Identifiers

PMID: 12051698
DOI: 10.1016/S0006-291X(02)00466-7

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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