Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The multiple mechanisms and modes of cell death after acetaminophen overdose

7 Apr 2025

Abstract excerpt

Acetaminophen (APAP)-induced liver injury and acute liver failure is a significant clinical problem worldwide; in addition, APAP overdoses in animals or in cell culture are used as popular models to study drug-induced liver injury mechanisms and test therapeutic interventions. Early assumptions that APAP toxicity is caused by a single mechanism resulting in a defined mode of cell death in hepatocytes had to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug-Induced Hepatotoxicity and Protection
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40364831
DOI: 10.37349/edd.2025.100569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The multiple mechanisms and modes of cell death after acetaminophen overdosePMID 40364831Read ↗

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or NecrosisSemantic proximity Read ↗

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen OverdoseSemantic proximity Read ↗

Chemical induction of hepatic apoptosis in rodentsSemantic proximity Read ↗

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systemsSemantic proximity Read ↗

Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen OverdoseSemantic proximity Read ↗

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injurySemantic proximity Read ↗

From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspectiveSemantic proximity Read ↗

Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and ToxicitySemantic proximity Read ↗

Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury.Semantic proximity Read ↗

Distinct Types of Cell Death and Implications in Liver Diseases: An Overview of Mechanisms and ApplicationSemantic proximity Read ↗

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.Semantic proximity Read ↗

Current Concepts of Mechanisms in Drug-Induced HepatotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.