Article

A systems approach reveals species differences in hepatic stress response capacity

2022-04-14

Abstract excerpt

<h4>ABSTRACT</h4> To minimise unexpected toxicities in early phase clinical studies of new drugs, it is vital to understand fundamental similarities and differences between preclinical test species and humans. We have used physiologically-based pharmacokinetic modelling to identify doses of the model hepatotoxin acetaminophen yielding similar hepatic burdens of the reactive metabolite N-acetyl-p-benzoquinoneimine...

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Literature Corpus work: fb37878f-35a7-5bfc-a93b-316fc6b32a20
DOI: 10.1101/2022.04.13.488145

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