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Article

A mouse model of severe halothane hepatitis based on human risk factors.

The Journal of pharmacology and experimental therapeutics - 1 May 2010

Dugan Christine M, MacDonald Allen E, Roth Robert A, Ganey Patricia E

Abstract excerpt

Halothane (2-bromo-2-chloro-1,1,1-trifluoro-ethane) is an inhaled anesthetic that induces severe, idiosyncratic liver injury, i.e., "halothane hepatitis," in approximately 1 in 20,000 human patients. We used known human risk factors (female sex, adult age, and genetics) as well as probable risk factors (fasting and inflammatory stress) to develop a murine model with characteristics of human halothane hepatitis....

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Source

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Identifiers

PMID: 20124411
DOI: 10.1124/jpet.109.164541
PMCID: PMC2872951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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