Article
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Chemical research in toxicology - 1 Feb 2007
Bourdi Mohammed, Eiras Daniel P, Holt Michael P, Webster Marie R, Reilly Timothy P, Welch Kevin D, Pohl Lance R
Abstract excerpt
Drug-induced hepatitis remains a challenging problem for drug development and safety because of the lack of animal models. In the current work, we discovered a unique interaction that makes mice deficient in both IL-10 and IL-4 (IL-10/4-/-) highly sensitive to the hepatotoxic effects of acetaminophen (APAP). Male C57Bl/6 wild type (WT) and mice deficient in one or more cytokines were treated with 120 mg/kg APAP....
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