Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity.

Hepatology (Baltimore, Md.) - 1 Aug 2010

Hu Bin, Colletti Lisa M

Abstract excerpt

UNLABELLED: Although acetaminophen is a commonly used analgesic, it can be highly hepatotoxic. This study seeks to further investigate the mechanisms involved in acetaminophen-induced hepatotoxicity and the role of chemokine (C-X-C motif) receptor 2 (CXCR2) receptor/ligand interactions in the liver's response to and recovery from acetaminophen toxicity. The CXC chemokines and their receptor, CXCR2, are important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaminophen
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genotype

Share to Mice, Knockout

Share to Receptors, Interleukin-8B

Share to X-Linked Inhibitor of Apoptosis Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20683965
DOI: 10.1002/hep.23715
PMCID: PMC2917773

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity.PMID 20683965Read ↗

Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury.Semantic proximity Read ↗

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.Semantic proximity Read ↗

IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice via mitochondrial dysfunction-induced apoptosisSemantic proximity Read ↗

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen OverdoseSemantic proximity Read ↗

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.Semantic proximity Read ↗

Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen OverdoseSemantic proximity Read ↗

miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 ExpressionSemantic proximity Read ↗

CD36 deficiency ameliorates drug-induced acute liver injury in mice.Semantic proximity Read ↗

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injurySemantic proximity Read ↗

The multiple mechanisms and modes of cell death after acetaminophen overdoseSemantic proximity Read ↗

The efficacy and safety of Acetaminophen for pain reliefSemantic proximity Read ↗

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.