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Article

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.

Frontiers in immunology - 1 Jan 2020

Hsu Chen-Yu, Lin Yung-Chang, Chang Li-Yuan, Huang Sheng-Kai, Huang Chien-Hao, Yang Chan-Keng, Huang Ching-Tai, Lin Chun-Yen

Abstract excerpt

Background: Acetaminophen (APAP) overdose is one of the major etiologies of liver failure. Hepatocyte necrosis induced by toxic metabolites of APAP can activate proinflammatory responses, including elastase-expressing neutrophils, to exacerbate liver injury. Myeloid-derived suppressor cells (MDSCs) increased in inflammation can inhibit proinflammatory responses. Our aim is to investigate the role of MDSC in...

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Source

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Identifiers

PMID: 33250891
DOI: 10.3389/fimmu.2020.574839
PMCID: PMC7673381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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