Article
The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury.
Toxicology and applied pharmacology - 1 Aug 2016
Mandal Mili, Gardner Carol R, Sun Richard, Choi Hyejeong, Lad Sonali, Mishin Vladimir, Laskin Jeffrey D, Laskin Debra L
Abstract excerpt
Macrophages have been shown to play a role in acetaminophen (APAP)-induced hepatotoxicity, contributing to both pro- and anti-inflammatory processes. In these studies, we analyzed the role of the spleen as an extramedullary source of hepatic macrophages. APAP administration (300mg/kg, i.p.) to control mice resulted in an increase in CD11b(+) infiltrating Ly6G(+) granulocytic and Ly6G(-) monocytic cells in the...
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