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Article

Regulation of Cytochromes P450 During Inflammation and Infection

1 Jan 1997

Abstract excerpt

Hepatic P450 activities are profoundly affected by various infectious and inflammatory stimuli, and this has clinical and toxicological consequences. Whereas the expression of most P450s in the liver is suppressed, some are induced. Many of the effects observed in vivo can be mimicked by pro-inflammatory cytokines and IFNs, and P450s are differentially regulated by these agents. Therefore, different cytokine...

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PMID: 9421688
DOI: 10.3109/03602539709002246

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