Article
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
Journal of gastroenterology and hepatology - 1 Jun 1996
Farrell G C, Frost L, Tapner M, Field J, Weltman M, Mahoney J
Abstract excerpt
The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined. In hepatic microsomes, the following were similar in susceptible and resistant animals: total cytochrome (CYP) P450 (P450), phenobarbital-inducible pathways of mixed function oxidation (androstenedione 6...
Topics
- Animals
- Arteries
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Fomepizole
- Genetic Predisposition to Disease
- Guinea Pigs
- Halothane
- Liver
- Liver Circulation
- Male
- Metyrapone