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Article

IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice.

Toxicology letters - 1 Aug 2018

Lee Hung-Chen, Liao Chia-Chih, Day Yuan-Ji, Liou Jiin-Tarng, Li Allen H, Liu Fu-Chao

Abstract excerpt

Acetaminophen (APAP) overdose results in the production of reactive oxygen species (ROS), hepatocyte necrosis, and cell death, and leads to acute liver failure. Interleukin-17 (IL-17), a pro-inflammatory cytokine, plays a key role in the recruitment of neutrophils into sites of inflammation and subsequent damage after liver ischemia-reperfusion injury. In this study, we employed IL-17 knockout (KO) mice to...

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Share to Acetaminophen
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotaxis, Leukocyte

Share to Cytochrome P-450 CYP2E1

Share to Extracellular Signal-Regulated MAP Kinases

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Source

Identifiers

PMID: 29689376
DOI: 10.1016/j.toxlet.2018.04.021

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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