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Article

Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure.

Hepatology (Baltimore, Md.) - 1 Apr 2014

Antoniades Charalambos Gustav, Khamri Wafa, Abeles Robin D, Taams Leonie S, Triantafyllou Evangelos, Possamai Lucia A, Bernsmeier Christine, Mitry Ragai R, O'Brien Alistair, Gilroy Derek, Goldin Robert, Heneghan Michael, Heaton Nigel, Jassem Wayel, Bernal William, Vergani Diego, Ma Yun, Quaglia Alberto, Wendon Julia, Thursz Mark

Abstract excerpt

UNLABELLED: Acetaminophen-induced acute liver failure (AALF) is characterized both by activation of innate immune responses and susceptibility to sepsis. Circulating monocytes and hepatic macrophages are central mediators of inflammatory responses and tissue repair processes during human AALF. Secretory leukocyte protease inhibitor (SLPI) modulates monocyte/macrophage function through inhibition of nuclear factor...

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Topics

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Share to Acetaminophen
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Chemical and Drug Induced Liver Injury

Share to HLA-DR Antigens

Share to Interleukin-6

Share to Monocytes

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Source

Identifiers

PMID: 24282114
DOI: 10.1002/hep.26933

Genes

SLPI
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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