Article
Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.
Molecular and cellular biology - 1 Apr 2002
Gravel Serge, Wellinger Raymund J
Abstract excerpt
The Saccharomyces cerevisiae Ku complex, while important for nonhomologous DNA end joining, is also necessary for maintaining wild-type telomere length and a normal chromosomal DNA end structure. Yeast cells lacking Ku can grow at 23 degrees C but are unable to do so at elevated temperatures due to an activation of DNA damage checkpoints. To gain insights into the mechanisms affected by temperature in such...
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