Article
Yeast Ku as a regulator of chromosomal DNA end structure.
Science (New York, N.Y.) - 1 May 1998
Gravel S, Larrivée M, Labrecque P, Wellinger R J
Abstract excerpt
During telomere replication in yeast, chromosome ends acquire an S-phase-specific overhang of the guanosine-rich strand. Here it is shown that in cells lacking Ku, a heterodimeric protein involved in nonhomologous DNA end joining, these overhangs are present throughout the cell cycle. In vivo cross-linking experiments demonstrated that Ku is bound to telomeric DNA. These results show that Ku plays a direct role...
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