Article
The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.
Genetics - 1 Oct 2009
Marvin Marcus E, Becker Marion M, Noel Pawan, Hardy Sue, Bertuch Alison A, Louis Edward J
Abstract excerpt
The yKu protein of Saccharomyces cerevisiae is important for genome stability by repressing recombination involving telomeric sequences. The mechanism of this repression is not known, but silent heterochromatin such as HML, HMR, and telomeres are compartmentalized at the nuclear periphery and yKu is proposed to interact with these regions and to play a role in telomeric silencing and tethering. We have utilized...
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