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Article

The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.

Genetics - 1 Oct 2009

Marvin Marcus E, Becker Marion M, Noel Pawan, Hardy Sue, Bertuch Alison A, Louis Edward J

Abstract excerpt

The yKu protein of Saccharomyces cerevisiae is important for genome stability by repressing recombination involving telomeric sequences. The mechanism of this repression is not known, but silent heterochromatin such as HML, HMR, and telomeres are compartmentalized at the nuclear periphery and yKu is proposed to interact with these regions and to play a role in telomeric silencing and tethering. We have utilized...

Topics

Binding Sites
Chromatin Immunoprecipitation
Chromosomes, Fungal
DNA, Fungal
DNA-Binding Proteins
Genomic Instability
Heterochromatin
Models, Biological
Mutation
Protein Binding
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Silent Information Regulator Proteins, Saccharomyces cerevisiae

Sirtuin 2

Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 19652176
DOI: 10.1534/genetics.109.106682
PMCID: PMC2766309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.PMID 19652176Read ↗

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