Article
The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini.
Molecular and cellular biology - 1 Nov 2003
Bertuch Alison A, Lundblad Victoria
Abstract excerpt
The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends. Toward defining these functional differences, we have identified eight mutations in the large...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.