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Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.

Nucleic acids research - 1 Dec 1996

Boulton S J, Jackson S P

Abstract excerpt

Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80, respectively) that binds to DNA ends. Mammalian cells lacking Ku are defective in DNA double-strand break (DSB) repair and in site-specific V(D)J recombination. Here, we describe the identification and characterisa...

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Mutation
Molecular Sequence Data
Amino Acid Sequence
DNA
DNA-Binding Proteins
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

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Identifiers

PMID: 8972848
DOI: 10.1093/nar/24.23.4639
PMCID: PMC146307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8972848-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.PMID 8972848Read ↗

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.Semantic proximity Read ↗

The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini.Semantic proximity Read ↗

Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.Semantic proximity Read ↗

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.Semantic proximity Read ↗

Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage.Semantic proximity Read ↗

Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.Semantic proximity Read ↗

Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo.Semantic proximity Read ↗

Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Multifaceted Roles of Ku70/80Semantic proximity Read ↗

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.Semantic proximity Read ↗

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.Semantic proximity Read ↗

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