Article
Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.
Current biology : CB - 21 May 1998
Laroche T, Martin S G, Gotta M, Gorham H C, Pryde F E, Louis E J, Gasser S M
Abstract excerpt
The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of double-stranded DNA in vitro and is required for repair of radiation-induced strand breaks and V(D)J recombination [1,2]. Deletion of the Saccharomyces cerevisiae genes HDF1 and HDF2--encoding yKu70p and yKu80p, res...
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