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Article

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.

Current biology : CB - 21 May 1998

Laroche T, Martin S G, Gotta M, Gorham H C, Pryde F E, Louis E J, Gasser S M

Abstract excerpt

The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of double-stranded DNA in vitro and is required for repair of radiation-induced strand breaks and V(D)J recombination [1,2]. Deletion of the Saccharomyces cerevisiae genes HDF1 and HDF2--encoding yKu70p and yKu80p, respectively--enhances radiation sensitivity in a rad52 background [3,4]. In addition to repair defects, the length of the...

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PMID: 9635192
DOI: 10.1016/s0960-9822(98)70252-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.PMID 9635192Read ↗

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.Semantic proximity Read ↗

Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.Semantic proximity Read ↗

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.Semantic proximity Read ↗

The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.Semantic proximity Read ↗

Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.Semantic proximity Read ↗

Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.Semantic proximity Read ↗

Dynamic regulation of single-stranded telomeres in Saccharomyces cerevisiae.Semantic proximity Read ↗

The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.Semantic proximity Read ↗

Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant.Semantic proximity Read ↗

In Saccharomyces cerevisiae, yKu and subtelomeric core X sequences repress homologous recombination near telomeres as part of the same pathway.Semantic proximity Read ↗

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