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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

The EMBO journal - 16 Sept 1996

Boulton S J, Jackson S P

Abstract excerpt

Ku, a heterodimer of polypeptides of approximately 70 kDa and 80 kDa (Ku70 and Ku80, respectively), binds avidly to DNA double-strand breaks (DSBs). Mammalian cells defective in Ku are hypersensitive to ionizing radiation due to a deficiency in DSB repair. Here, we show that the simple inactivati...

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DNA-Binding Proteins
Gene Deletion
Phenotype
Plasmids
Restriction Mapping
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

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PMID: 8890183
PMCID: PMC452249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8890183-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.PMID 8890183Read ↗

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Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage.Semantic proximity Read ↗

Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms.Semantic proximity Read ↗

The Multifaceted Roles of Ku70/80Semantic proximity Read ↗

Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.Semantic proximity Read ↗

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Semantic proximity Read ↗

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences.Semantic proximity Read ↗

Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.Semantic proximity Read ↗

The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini.Semantic proximity Read ↗

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