Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

The EMBO journal - 16 Sept 1996

Boulton S J, Jackson S P

Abstract excerpt

Ku, a heterodimer of polypeptides of approximately 70 kDa and 80 kDa (Ku70 and Ku80, respectively), binds avidly to DNA double-strand breaks (DSBs). Mammalian cells defective in Ku are hypersensitive to ionizing radiation due to a deficiency in DSB repair. Here, we show that the simple inactivation of the Saccharomyces cerevisiae Ku70 homologue (Yku70p), does not lead to increased radiosensitivity. However, yku70...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Gene Deletion
Share to Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plasmids

Share to Restriction Mapping

Share to Saccharomyces cerevisiae

Share to Sequence Analysis, DNA

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8890183
PMCID: PMC452249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.PMID 8890183Read ↗

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.Semantic proximity Read ↗

Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage.Semantic proximity Read ↗

Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms.Semantic proximity Read ↗

The Multifaceted Roles of Ku70/80Semantic proximity Read ↗

Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.Semantic proximity Read ↗

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Semantic proximity Read ↗

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences.Semantic proximity Read ↗

Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.Semantic proximity Read ↗

The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini.Semantic proximity Read ↗

Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.