Article
Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant.
EMBO reports - 1 Mar 2001
Teo S H, Jackson S P
Abstract excerpt
Ku is a conserved heterodimeric DNA-binding protein that plays critical roles in DNA repair and telomere homeostasis. In Saccharomyces cerevisiae, deletion of YKU70 or YKU80 results in an inability to grow at 37 degrees C. This is suppressed by overexpression of several components of telomerase (...
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