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Article

Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant.

EMBO reports - 1 Mar 2001

Teo S H, Jackson S P

Abstract excerpt

Ku is a conserved heterodimeric DNA-binding protein that plays critical roles in DNA repair and telomere homeostasis. In Saccharomyces cerevisiae, deletion of YKU70 or YKU80 results in an inability to grow at 37 degrees C. This is suppressed by overexpression of several components of telomerase (EST1, EST2 and TLC1). We show that overexpression of EST2 or TLC1 in yku80 mutants does not restore efficient DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11266360
DOI: 10.1093/embo-reports/kve038
PMCID: PMC1083835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant.PMID 11266360Read ↗

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